alkaline extraction statistical design
7 Reasons Process Optimization Fails in Ferulic Scale‑Up (Fix)
A 2022 study reported an R² of 0.96 for a multi-parameter prediction model, yet ferulic acid scale-up often fails because bench experiments miss interaction effects and real-time variability. The result is a sudden drop in yield and spikes in batch-to-batch inconsistency. "R² = 0.96" - Nature Process